Demographics and health history across dementia diagnoses

 
   Lead Investigator:    Zachary Miller
   Institution      :    UCSF Memory and Aging Center
   E-Mail           :    zachary.miller2@ucsf.edu
   Proposal ID      :    736



   Proposal Description:
   In the past we have shown that past medical history of autoimmune disease (ZA     Miller et al., JNNP 2013) and developmental differences including hand            preference (ZA Miller et al., BRAIN 2013) display differential effects on         targeting specific neuroanatomies. We are looking to validate on larger cohorts   demographic differences across dementia diagnoses. Analyses will take a           multi-domain approach starting with diagnosis and demographic information of      individuals within groups to investigate associations between their neurologic    exam, neuropsychological performance, neuroimaging, and genetic markers.          Because demographic and health history information predates neurodegenerative     symptom onset by many decades, this work has the potential for facilitating       predictive and preventative strategies for dementia.